Luo A, Tian Y, Jin S
Department of Anesthesiology, Tongji Hospital, Tongji Medical University, Wuhan 430030.
J Tongji Med Univ. 2000;20(1):77-8. doi: 10.1007/BF02887684.
The experimental results showed that the level of CAMP, the ratio of cAPM to cGMP, IL-2R expression and IL-2 production in vitro in lymphocytes immediate and 2 weeks after cardiopulmonary bypass (CPB) were significantly lower than those before anesthetics in the patients undergoing cardiac surgery with CPB. These findings suggested that CPB could cause serious damage to adrenergic beta receptor-adenylate cyclase system on circulating lymphocytes surfaces, which might be one of the mechanisms resulting in immunosuppression after open heart surgery with CPB.
实验结果显示，在接受体外循环心脏手术的患者中，体外循环（CPB）即刻及2周后淋巴细胞内的环磷酸腺苷（CAMP）水平、环磷酸腺苷与环磷酸鸟苷的比值、白细胞介素-2受体（IL-2R）表达及白细胞介素-2（IL-2）产生均显著低于麻醉前。这些发现提示，CPB可对循环淋巴细胞表面的肾上腺素能β受体-腺苷酸环化酶系统造成严重损害，这可能是CPB心脏直视手术后导致免疫抑制的机制之一。
