Medzihradszky Kálmán
Research Group of Peptide Chemistry, Hungarian Academy of Sciences, Budapest, Hungary.
J Pept Sci. 2003 Jun;9(6):333-53. doi: 10.1002/psc.469.
Since the discovery of the opioid receptors and their endogenous ligands an immense research work has been devoted to the exploration of their specificity, the mechanism of ligand binding and ligand-receptor interactions. One of the main goals has been the location and characterization of the binding sites. The present review compiles the results achieved in this field in the last quarter of a century, and puts some questions concerning the success of these efforts.
自从发现阿片受体及其内源性配体以来，大量的研究工作致力于探索它们的特异性、配体结合机制以及配体 - 受体相互作用。主要目标之一是确定结合位点的位置并对其进行表征。本综述汇集了过去二十五年在该领域所取得的成果，并对这些努力的成效提出了一些问题。
