脂蛋白在血清对内毒素的灭活作用中的角色。
The role of lipoproteins in inactivation of endotoxin by serum.
作者信息
Northoff H, Flegel W A, Yurttas R, Weinstock C
机构信息
DRK-Blutspendezentrale Ulm, FRG.
出版信息
Beitr Infusionsther. 1992;30:195-7.
PMID:1284705
Abstract
Lipopolysaccharide (LPS)-induced release of cytokines from human monocytes can be prevented by previous interference of serum with LPS. This inactivation is a function of lipoproteins. Here we show that low-density lipoproteins as well as high-density lipoproteins can inactivate LPS. The effects of heparin and EDTA on LPS inactivation by serum are also described.
摘要
脂多糖（LPS）诱导人单核细胞释放细胞因子的过程可通过预先用血清干扰LPS来阻止。这种失活作用是脂蛋白的功能。在此我们表明，低密度脂蛋白以及高密度脂蛋白均可使LPS失活。文中还描述了肝素和乙二胺四乙酸（EDTA）对血清使LPS失活的影响。
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