ABO血型不相合的骨髓移植

ABO-incompatible bone marrow transplantation.

作者信息

Wiesneth M, Hertenstein B, Bunjes D, Schmeiser T, Maccari B, Northoff H, Laasch H, Heit W, Arnold R, Heimpel H

机构信息

Red Cross Blood Bank Ulm, FRG.

出版信息

Beitr Infusionsther. 1992;30:354-8.

PMID:1284733

Abstract

In the past 10 years 201 HLA-identical bone marrow transplantations (BMT) were performed with major ABO incompatibility in 41 (20%) and minor ABO incompatibility in 35 (18%) patients. ABO compatibility between donor and recipient showed no influence on granulocyte and platelet recovery after BMT. Erythrocyte reconstitution was significantly (p < 0.01) delayed for about 1 week in major ABO-incompatible BMT. In addition, a pure red cell aplasia lasting for 2-5 months occurred in 6 out of 21 blood group 0 patients who received transplants of group A. The rate of graft rejection, incidence of graft-versus-host disease as well as the leukemic relapse rate were similar in ABO-compatible and ABO-incompatible BMT. The probability of a 10-year survival after BMT is independent of ABO compatibility between donor and recipient.

摘要

在过去10年中，进行了201例人类白细胞抗原（HLA）相合的骨髓移植（BMT），其中41例（20%）存在主要ABO血型不合，35例（18%）存在次要ABO血型不合。供者与受者之间的ABO血型相容性对BMT后粒细胞和血小板的恢复没有影响。在主要ABO血型不合的BMT中，红细胞重建明显延迟（p<0.01）约1周。此外，在接受A型血移植的21例O型血患者中，有6例发生了持续2至5个月的纯红细胞再生障碍。在ABO血型相合和不相合的BMT中，移植物排斥率、移植物抗宿主病发生率以及白血病复发率相似。BMT后10年生存率与供者和受者之间的ABO血型相容性无关。