抗-D单克隆抗体反应性评估DGTI研讨会的结果
Results of the DGTI workshop on the evaluation of the reactivity of monoclonal anti-D.
作者信息
Sonneborn H H, Darda C, Ernst M, Flegel W A, Helmbold W, Kasulke D, Kühnl P, Mueller-Eckhardt C, Northoff H, Poschmann A
机构信息
Biotest AG, Research Department, Dreieich, FRG.
出版信息
Beitr Infusionsther. 1992;30:382-7.
All D+ samples were detected by all monoclonal antibodies (mabs) without any problem. Very few of the 3,000 D- samples showed a +/- to ++ reaction with some of the IgG type mabs using the Coombs technique. It is still open whether these are specific reactions with weakly positive samples, which were negative with polyclonal sera. IgM type mabs detected up to 100% of the Du samples dependent on the Rh phenotype and the technique used (CCDuee > CcDuee > ccDuEe). Most of the CCDuee samples reacted very strongly and should no longer be regarded as Du.
所有D+样本均可被所有单克隆抗体（mabs）顺利检测出来。在3000份D-样本中，只有极少数样本在使用库姆斯技术时与某些IgG型单克隆抗体呈现出+/-到++的反应。这些反应是否是与多克隆血清检测为阴性的弱阳性样本的特异性反应仍有待确定。IgM型单克隆抗体对Du样本的检测率高达100%，具体取决于Rh表型和所使用的技术（CCDuee > CcDuee > ccDuEe）。大多数CCDuee样本反应非常强烈，不应再被视为Du。
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