Kamal Baher A, Ali Gaber A, Taha Saud A
Department of Urology, College of Medicine, Kingdom of Saudi Arabia.
Saudi Med J. 2003 Jun;24(6):665-8.
The aim of this study is to find out the age-specific and population-specific values of prostate specific antigen (PSA) among Saudi men. Normal values for different age groups between 40 and 89 years will be obtained.
The study was conducted in King Fahd Hospital of the University, Al-Khobar, Kingdom of Saudi Arabia. The total free and percent free PSA were measured for Saudi men who were free of prostate cancer by digital rectal examination (DRE) and with PSA value of <4 ng/ml. Transrectal ultrasonography and needle biopsy were performed in those with suspicious DRE or PSA >4 ng/ml. A total of 567 cancer free Saudi men were included in this study. All men were divided into 5 groups; each 10 years interval starting from the age of 40 years.
The mean values of total PSA were 0.87 for men 40-49 years, 1.36 for men 50-59 years, 1.81 for men 60-69 years, 2.32 for men 70-79 years and 2.36 for men 80-89 years. The percent free PSA was >30% in all age groups. When those with PSA <4 ng/ml were considered, the percent free PSA was the same and only 16.6% of them had a ratio of < or =18%. The upper limit of normal PSA was near to that of Chinese and Korean.
Normal mean PSA values for Saudi men are lower than the reported values. The percent free PSA for men having PSA <4 ng/ml is applicable. Racial variations of PSA values were observed.
本研究旨在找出沙特男性中前列腺特异性抗原（PSA）的年龄特异性和人群特异性值。将获取40至89岁不同年龄组的正常值。
该研究在沙特阿拉伯王国胡拜尔市法赫德国王大学医院进行。对通过直肠指检（DRE）未患前列腺癌且PSA值<4 ng/ml的沙特男性测量其总游离PSA和游离PSA百分比。对DRE可疑或PSA>4 ng/ml的患者进行经直肠超声检查和穿刺活检。本研究共纳入567名无癌沙特男性。所有男性分为5组；从40岁开始，每组间隔10年。
40 - 49岁男性的总PSA平均值为0.87，50 - 59岁男性为1.36，60 - 69岁男性为1.81，70 - 79岁男性为2.32，80 - 89岁男性为2.36。所有年龄组的游离PSA百分比均>30%。当考虑PSA<4 ng/ml的患者时，游离PSA百分比相同，其中只有16.6%的患者比值≤18%。正常PSA上限接近中国和韩国人群。
沙特男性的正常PSA平均值低于报告值。PSA<4 ng/ml男性的游离PSA百分比是适用的。观察到PSA值存在种族差异。
