一些4-氨基-3-喹啉羧酸衍生物的结构与生物活性。具有抗菌特性的喹啉衍生物的定量构效关系分析。
Structure and biological activity of some 4-amino-3-cinnolinecarboxylic acid derivatives. QSAR analysis of cinnoline derivatives with antibacterial properties.
作者信息
Brzezińska Elzbieta, Stańczak Andrzej, Ochocki Zbigniew
机构信息
Department of Analytical Chemistry, Medical University of Lódź, 1 Muszyńskiego Str., 90-151 Lódź, Poland.
出版信息
Acta Pol Pharm. 2003 Jan-Feb;60(1):15-20.
PMID:12848362
Abstract
QSAR analysis was done in a group of cinnoline-3-carboxylic acid derivatives with antibacterial properties. Several physicochemical parameters, which characterize the variability of the structure of the 15 studied compounds, were compared as to their activity against gram-positive cocci, gram-negative bacilli and gram-positive bacilli strains. The physicochemical parameters with predictive value were found.
摘要
对一组具有抗菌特性的噌啉-3-羧酸衍生物进行了定量构效关系（QSAR）分析。比较了15种研究化合物结构变异性的几个物理化学参数，以考察它们对革兰氏阳性球菌、革兰氏阴性杆菌和革兰氏阳性杆菌菌株的活性。发现了具有预测价值的物理化学参数。
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