使用贫血大鼠评估鲣鱼黑肌肉中铁的生物利用度。

Evaluation of iron bioavailability from bonito dark muscle using anemic rats.

作者信息

Matsumoto Junichi, Mori Nahomi, Doi Mikiharu, Kishida Taro, Ebihara Kiyoshi

机构信息

Marutomo Company Ltd., 1696 Kominato, Iyo, Ehime 799-3192, Japan.

出版信息

J Agric Food Chem. 2003 Jul 16;51(15):4478-82. doi: 10.1021/jf021246l.

DOI:10.1021/jf021246l

PMID:12848529

Abstract

The bioavailability of iron from ferrous sulfate (FeII-S), heme iron prepared from hemoglobin (HIP), and bonito dark muscle (BDM) was assessed in anemic rats using a hemoglobin regeneration efficiency (HRE) method. Freeze-dried BDM (FD), boiled and freeze-dried BDM (B/FD), and boiled and smoke-dried BDM (B/SD) were used as BDM source. Rats were made anemic by feeding on an iron-deficient diet for 28 days. To replete their iron levels, anemic rats were then fed on a diet containing iron at a level of 17 ppm for 14 days. Rats receiving FeII-S gained significantly more weight and had greater food intake and higher HRE compared to the other four groups. The bioavailability of iron from HIP was poor compared with that from FeII-S and BDM. When the HRE of rats fed FeII-S was 100, that of rats fed BDF was approximately 80. These results suggest that BMD is an effective dietary source of iron.

摘要

采用血红蛋白再生效率（HRE）法，在贫血大鼠中评估了硫酸亚铁（FeII-S）、由血红蛋白制备的血红素铁（HIP）和鲣鱼黑肌肉（BDM）中铁的生物利用度。冻干的BDM（FD）、煮沸并冻干的BDM（B/FD）以及煮沸并烟熏干燥的BDM（B/SD）用作BDM来源。通过喂食缺铁饮食28天使大鼠贫血。为了补充它们的铁水平，然后给贫血大鼠喂食含铁量为17 ppm的饮食14天。与其他四组相比，接受FeII-S的大鼠体重增加显著更多，食物摄入量更大，HRE更高。与FeII-S和BDM相比，HIP中铁的生物利用度较差。当喂食FeII-S的大鼠的HRE为100时，喂食BDF的大鼠的HRE约为80。这些结果表明，BDM是一种有效的铁膳食来源。