淋巴瘤患者在使用细胞毒性药物治疗前、治疗期间及治疗后的唾液流量和成分。

Salivary flow and composition in lymphoma patients before, during and after treatment with cytostatic drugs.

作者信息

Laine P, Meurman J H, Tenovuo J, Murtomaa H, Lindqvist C, Pyrhönen S, Teerenhovi L

机构信息

Institute of Dentistry, University of Kuopio, Finland.

出版信息

Eur J Cancer B Oral Oncol. 1992 Oct;28B(2):125-8. doi: 10.1016/0964-1955(92)90040-8.

DOI:10.1016/0964-1955(92)90040-8

PMID:1284874

Abstract

To investigate the effect of modern, intensive chemotherapy on salivary flow rate and composition, 79 patients suffering from Hodgkin's disease or non-Hodgkin lymphoma were studied before, during and after administration of cytostatic drugs. 49 patients (mean age 49.9 years, 30 men, 19 women) completed the 1-year study. All patients who received radiotherapy or medication other than cytostatics were excluded. The results showed no marked differences in stimulated salivary flow rates, buffering capacities and amylase and total protein concentrations between the beginning and the end of the 12 month trial. However, significant increases in albumin secretion into saliva and salivary lysozyme concentrations were observed. Total salivary IgG, IgA and IgM concentrations decreased significantly during the cancer therapy but values returned to the baseline levels after termination of treatment. Despite the well-known cytolytic effect of anticancer drugs, chemotherapy need not therefore be permanently detrimental to saliva.

摘要

为研究现代强化化疗对唾液流速和成分的影响，我们对79例霍奇金病或非霍奇金淋巴瘤患者在使用细胞毒性药物之前、期间和之后进行了研究。49例患者（平均年龄49.9岁，30例男性，19例女性）完成了为期1年的研究。所有接受过放疗或除细胞毒性药物以外其他药物治疗的患者均被排除。结果显示，在为期12个月的试验开始和结束时，刺激唾液流速、缓冲能力、淀粉酶和总蛋白浓度没有明显差异。然而，观察到唾液中白蛋白分泌和唾液溶菌酶浓度显著增加。在癌症治疗期间，唾液中总IgG、IgA和IgM浓度显著下降，但在治疗结束后恢复到基线水平。尽管抗癌药物具有众所周知的细胞溶解作用，但化疗不一定会对唾液产生永久性损害。