4-（氨甲基）-1-芳基-2-吡咯烷酮，一类新型单胺氧化酶B失活剂。
4-(Aminomethyl)-1-aryl-2-pyrrolidinones, a new class of monoamine oxidase B inactivators.
作者信息
Ding C Z, Silverman R B
机构信息
Department of Chemistry, Northwestern University, Evanston, Illinois 60208-3113.
出版信息
J Enzyme Inhib. 1992;6(3):223-31. doi: 10.3109/14756369209020172.
PMID:1284959
Abstract
Both 4-(aminomethyl)-1-phenyl-2-pyrrolidinone (4a) and 4-(aminomethyl)-1- (methoxyphenyl)-2-pyrrolidinone (4b) hydrochlorides were synthesized via a six-step sequence, which represents a general approach to 1,4-disubstituted 2-pyrrolidinones. Both of these compounds inactivated monoamine oxidase B and represent the first in a new class of monomamine oxidase inactivators.
摘要
4-(氨甲基)-1-苯基-2-吡咯烷酮（4a）盐酸盐和4-(氨甲基)-1-(甲氧基苯基)-2-吡咯烷酮（4b）盐酸盐均通过六步反应合成，这是一种合成1,4-二取代2-吡咯烷酮的通用方法。这两种化合物均可使单胺氧化酶B失活，是新型单胺氧化酶失活剂中的首例。
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