Birnbaum Linda S, Staskal Daniele F, Diliberto Janet J
Experimental Toxicology Division (MD B 143-01), Office of Research and Development, United States Environmental Protection Agency, 109 TW Alexander Drive, Research Triangle Park, NC 27709, USA.
Environ Int. 2003 Sep;29(6):855-60. doi: 10.1016/S0160-4120(03)00106-5.
This article reviews the state of the science regarding the health effects of polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs). While thousands of articles have been published on the health effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and related polychlorinated dibenzodioxins (PCDDs) and dibenzofurans (PCDFs), little is know about the brominated and mixed chloro/bromo homologs. Available literature suggests that brominated compounds have similar toxicity profiles to their chlorinated homologs. However, further research investigating health effects will only be useful if exposure scenarios truly exist. Current exposure data is extremely limited, posing a major data gap in assessing potential risk of these chemicals. The rapid increase in the use of brominated flame retardants has raised the level of environmental concern regarding PBDDs/PBDFs as it is likely that human, as well as wildlife, exposure to brominated dioxins and furans will increase with their use.
本文综述了多溴代二苯并对二噁英（PBDDs）和二苯并呋喃（PBDFs）对健康影响的科学现状。虽然已经发表了数千篇关于2,3,7,8-四氯二苯并对二噁英及相关多氯代二苯并二噁英（PCDDs）和二苯并呋喃（PCDFs）对健康影响的文章，但对于溴代以及氯/溴混合同系物却知之甚少。现有文献表明，溴代化合物与其氯代同系物具有相似的毒性特征。然而，只有在真正存在接触情况时，进一步研究其对健康的影响才会有用。目前的接触数据极其有限，这在评估这些化学品的潜在风险方面造成了一个重大的数据缺口。溴代阻燃剂使用的迅速增加，引发了对PBDDs/PBDFs的环境关注，因为随着其使用，人类以及野生动物接触溴代二噁英和呋喃的可能性很可能会增加。
