Watts Paul, Haswell Stephen J
Department of Chemistry, University of Hull, Cottingham Road, Hull, UK HU6 7RX.
Drug Discov Today. 2003 Jul 1;8(13):586-93. doi: 10.1016/s1359-6446(03)02732-6.
To develop a new generation of drugs, pharmaceutical companies need to be able to synthesize and screen novel chemicals with enhanced speed. New technology that would enable a cost-neutral increase in the number of potential drug candidates would provide a distinct competitive advantage. The miniaturisation of chemical reactors offers many fundamental and practical advantages of relevance to the pharmaceutical industry, which is constantly searching for controllable, information-rich, high-throughput and environmentally friendly methods of producing compounds with a high degree of chemical selectivity. This article reviews the current and future applications of micro reactors that could enhance the drug discovery process.
为了开发新一代药物，制药公司需要能够以更快的速度合成和筛选新型化学物质。能够在不增加成本的情况下增加潜在药物候选物数量的新技术将提供显著的竞争优势。化学反应器的小型化具有许多与制药行业相关的基本和实际优势，制药行业一直在寻找可控、信息丰富、高通量且环境友好的方法来生产具有高度化学选择性的化合物。本文综述了可增强药物发现过程的微反应器的当前及未来应用。
