Geminin与p53：人类癌细胞再复制的阻碍因素 - Suppr

Geminin and p53: deterrents to rereplication in human cancer cells.

作者信息

Saxena Sandeep, Dutta Anindya

机构信息

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, Massachusetts 02115, USA.

出版信息

Cell Cycle. 2003 Jul-Aug;2(4):283-6.

PMID:12851473

Abstract

摘要

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Geminin and p53: deterrents to rereplication in human cancer cells.

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引用本文的文献

Regulation of DNA Replication Licensing and Re-Replication by Cdt1.

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p53 activates G₁ checkpoint following DNA damage by doxorubicin during transient mitotic arrest.

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Orc2 protects ORCA from ubiquitin-mediated degradation.

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Proposed megakaryocytic regulon of p53: the genes engaged to control cell cycle and apoptosis during megakaryocytic differentiation.

Physiol Genomics. 2012 Jun 15;44(12):638-50. doi: 10.1152/physiolgenomics.00028.2012. Epub 2012 May 1.

Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cells.

Breast Cancer Res. 2011 May 19;13(3):R53. doi: 10.1186/bcr2884.

Geminin stabilizes Cdt1 during meiosis in Xenopus oocytes.

J Biol Chem. 2009 Oct 2;284(40):27235-42. doi: 10.1074/jbc.M109.008854. Epub 2009 Aug 5.

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Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.

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相似文献

Geminin and p53: deterrents to rereplication in human cancer cells.

Cell Cycle. 2003 Jul-Aug;2(4):283-6.

Triggering ubiquitination of a CDK inhibitor at origins of DNA replication.

Nat Cell Biol. 2001 Aug;3(8):715-22. doi: 10.1038/35087026.

Cyclin-dependent kinases and S phase control in mammalian cells.

Cell Cycle. 2003 Jul-Aug;2(4):316-24.

How to activate p53.

Curr Biol. 2000 Apr 20;10(8):R315-7. doi: 10.1016/s0960-9822(00)00439-5.

Cell cycle. Checking two steps.

Nature. 2001 Apr 12;410(6830):766-7. doi: 10.1038/35071218.

Checkpoints: it takes more than time to heal some wounds.

Curr Biol. 2000;10(24):R908-11. doi: 10.1016/s0960-9822(00)00849-6.

A p53-dependent checkpoint pathway prevents rereplication.

Mol Cell. 2003 Apr;11(4):997-1008. doi: 10.1016/s1097-2765(03)00099-6.

Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage.

Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5056-61. doi: 10.1073/pnas.0408595102. Epub 2005 Mar 23.

Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage.

Mol Cell. 2000 Sep;6(3):649-59. doi: 10.1016/s1097-2765(00)00063-0.

Chek2ing out the p53 pathway: can Puma lead the way?

Cell Cycle. 2011 May 15;10(10):1524. doi: 10.4161/cc.10.10.15514.

引用本文的文献

Regulation of DNA Replication Licensing and Re-Replication by Cdt1.

Int J Mol Sci. 2021 May 14;22(10):5195. doi: 10.3390/ijms22105195.

p53 activates G₁ checkpoint following DNA damage by doxorubicin during transient mitotic arrest.

Oncotarget. 2015 Mar 10;6(7):4804-15. doi: 10.18632/oncotarget.3103.

Orc2 protects ORCA from ubiquitin-mediated degradation.

Cell Cycle. 2012 Oct 1;11(19):3578-89. doi: 10.4161/cc.21870. Epub 2012 Aug 30.

Proposed megakaryocytic regulon of p53: the genes engaged to control cell cycle and apoptosis during megakaryocytic differentiation.

Physiol Genomics. 2012 Jun 15;44(12):638-50. doi: 10.1152/physiolgenomics.00028.2012. Epub 2012 May 1.

Geminin overexpression prevents the completion of topoisomerase IIα chromosome decatenation, leading to aneuploidy in human mammary epithelial cells.

Breast Cancer Res. 2011 May 19;13(3):R53. doi: 10.1186/bcr2884.

Geminin stabilizes Cdt1 during meiosis in Xenopus oocytes.

J Biol Chem. 2009 Oct 2;284(40):27235-42. doi: 10.1074/jbc.M109.008854. Epub 2009 Aug 5.

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer.

Nature. 2009 Apr 9;458(7239):732-6. doi: 10.1038/nature07884.

Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.

J Biol Chem. 2008 Sep 12;283(37):25356-25363. doi: 10.1074/jbc.M802667200. Epub 2008 Jul 10.

DNA replication licensing and cell cycle kinetics of oligodendroglial tumours.

Br J Cancer. 2004 Jul 19;91(2):262-9. doi: 10.1038/sj.bjc.6601949.

Geminin and p53: deterrents to rereplication in human cancer cells.

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Geminin and p53: deterrents to rereplication in human cancer cells.

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