Salcedo Rosalba, Oppenheim Joost J
Laboratory of Molecular Immunoregulation, Division of Basic Sciences, National Cancer Institute at Frederick, Frederick, MD 21702-1201, USA.
Microcirculation. 2003 Jun;10(3-4):359-70. doi: 10.1038/sj.mn.7800200.
Chemokines are small proteins that act as cell attractants via the activation of G protein-coupled receptors. Chemokines play an important role in several pathophysiological processes such as inflammation and immunity. Many proinflammatory chemokines also support the development of vascular blood supply at the site of inflammation. Similarly, tumor-generated chemokines can contribute to tumor growth by promoting angiogenesis. Recently, significant advances have been made in understanding the contribution of chemokines to the angiogenesis process. This review will discuss first the evidence supporting the direct contribution of different chemokine subfamily members, including CC, CXC, and CX3C chemokines, as positive or negative regulators of the angiogenesis process based on the expression of their cognate receptors on endothelial cells. Additionally, the relationship between classic angiogenic factors and chemokine receptor expression on endothelial cells, and the implications of chemokine production by cancer cells will be analyzed with particular emphasis on the CXCL12/stromal-cell derived factor-1 interaction with CXCR4.
趋化因子是一类小蛋白，通过激活G蛋白偶联受体发挥细胞吸引剂的作用。趋化因子在多种病理生理过程中发挥重要作用，如炎症和免疫。许多促炎趋化因子还支持炎症部位血管血液供应的发展。同样，肿瘤产生的趋化因子可通过促进血管生成来促进肿瘤生长。最近，在理解趋化因子对血管生成过程的贡献方面取得了重大进展。本综述将首先讨论支持不同趋化因子亚家族成员直接贡献的证据，包括CC、CXC和CX3C趋化因子，基于它们在内皮细胞上同源受体的表达，作为血管生成过程的正或负调节因子。此外，将分析经典血管生成因子与内皮细胞上趋化因子受体表达之间的关系，以及癌细胞产生趋化因子的影响，特别强调CXCL12/基质细胞衍生因子-1与CXCR4的相互作用。
