葡萄糖和胰岛素对人体下体负压期间手臂跨毛细血管液体吸收的影响。
Influence of glucose and insulin on transcapillary fluid absorption from the arm during lower body negative pressure in man.
作者信息
Olsen H, Groop L, Länne T
机构信息
Department of Internal Medicine, Helsingborg Hospital, 251 87 Helsingborg, Sweden.
出版信息
Eur J Appl Physiol. 2003 Sep;90(1-2):138-43. doi: 10.1007/s00421-003-0894-3. Epub 2003 Jul 15.
This study examined the influence of insulin and glucose on the transcapillary fluid absorption during lower body negative pressure (LBNP) in humans. Ten healthy males [23 (1) years] were exposed to LBNP of 45 cmH(2)O on two occasions: (1) before and during a hyperinsulinaemic clamp (HI) and (2) before and during a hyperglycaemic clamp (HG). Transcapillary fluid absorption and blood flow were recorded with volumetric technique. Forearm blood flow increased during HI from 2.3 (0.3) ml (100 ml)(-1) min(-1) to 3.3 (0.5) ml (100 ml)(-1) min(-1) ( P<0.05). The haemodynamic response to LBNP was similar during HI and HG compared with control LBNP. Transcapillary fluid absorption during LBNP increased during HG from 0.044 (0.007) ml (100 ml)(-1) min(-1) to 0.059 (0.009) ml (100 ml)(-1) min(-1 )( P<0.01), whereas it was unchanged during HI. In conclusion, hyperglycaemia augments transcapillary fluid absorption from skeletal muscle and skin during LBNP whereas hyperinsulinaemia has no such effect. This indicates that in human hyperglycaemia contributes to plasma volume restitution during hypovolaemic circulatory stress.
本研究探讨了胰岛素和葡萄糖对人体下体负压（LBNP）期间跨毛细血管液体吸收的影响。10名健康男性[23（1）岁]在两种情况下接受45 cmH₂O的LBNP：（1）在高胰岛素钳夹（HI）之前和期间；（2）在高血糖钳夹（HG）之前和期间。采用容积技术记录跨毛细血管液体吸收和血流情况。HI期间，前臂血流量从2.3（0.3）ml（100 ml）⁻¹ min⁻¹增加至3.3（0.5）ml（100 ml）⁻¹ min⁻¹（P<0.05）。与对照LBNP相比，HI和HG期间对LBNP的血流动力学反应相似。LBNP期间的跨毛细血管液体吸收在HG期间从0.044（0.007）ml（100 ml）⁻¹ min⁻¹增加至0.059（0.009）ml（100 ml）⁻¹ min⁻¹（P<0.01），而在HI期间保持不变。总之，高血糖在LBNP期间增强了骨骼肌和皮肤的跨毛细血管液体吸收，而高胰岛素血症则无此作用。这表明在人类中，高血糖有助于在低血容量循环应激期间恢复血浆容量。
Zotero 插件