Länne T, Edfeldt H, Quittenbaum S, Lundvall J
Department of Clinical Physiology, Malmô General Hospital, Sweden.
Acta Physiol Scand. 1992 Nov;146(3):313-9. doi: 10.1111/j.1748-1716.1992.tb09425.x.
Our previous studies strongly indicate that the capillary filtration coefficient (CFC) in skeletal muscle and skin of man is much larger than previously believed, or about 0.050 ml min-1 100 ml-1 mmHg-1. The hypothesis that this large capillary fluid permeability is a factor of primary importance for plasma volume control was approached. Experimental hypovolaemia induced by lower body negative pressure (LBNP of 70-95 cmH2O) was associated with a rapid net fluid gain from the studied upper arm into the circulation of 0.17 ml min-1 100 ml-1 tissue. The transcapillary driving force for this fluid transfer, probably caused by adrenergic adjustment of vascular resistance, with a decline of capillary pressure, was relatively small, or 1.7 mmHg on average. CFC was instead very high during LBNP, increasing from a control value of 0.054 +/- 0.004 (SE) to no less than 0.097 +/- 0.007 ml min-1 100 ml-1 mmHg-1, probably reflecting an increased number of effectively perfused capillaries. It is suggested that the large capillary fluid permeability in skeletal muscle and skin of man, with large tissue mass and fluid reservoir, may be of great functional importance for plasma volume control after blood loss and also in other (patho)physiological situations. As demonstrated, it can thus permit rapid transfer of large fluid volumes into the circulation and, perhaps of special importance, with only small transcapillary driving force (capillary pressure decline).(ABSTRACT TRUNCATED AT 250 WORDS)
我们之前的研究有力地表明，人类骨骼肌和皮肤中的毛细血管滤过系数（CFC）比之前认为的要大得多，约为0.050毫升·分钟⁻¹·100毫升⁻¹·毫米汞柱⁻¹。我们探讨了这一较大的毛细血管液体通透性是血浆容量控制的一个至关重要因素的假说。由下体负压（70 - 95厘米水柱的下体负压）诱导的实验性血容量减少，与从所研究的上臂快速净液体进入循环的量为0.17毫升·分钟⁻¹·100毫升⁻¹组织相关。这种液体转移的跨毛细血管驱动力，可能是由血管阻力的肾上腺素能调节导致毛细血管压力下降引起的，相对较小，平均为1.7毫米汞柱。相反，在下体负压期间CFC非常高，从对照值0.054±0.004（标准误）增加到不少于0.097±0.007毫升·分钟⁻¹·100毫升⁻¹·毫米汞柱⁻¹，这可能反映了有效灌注毛细血管数量的增加。有人提出，人类骨骼肌和皮肤中较大的毛细血管液体通透性，具有大量的组织质量和液体储存库，对于失血后以及其他（病理）生理情况下的血浆容量控制可能具有重要的功能意义。如所证明的，因此它可以允许大量液体快速转移到循环中，而且也许特别重要的是，只需较小的跨毛细血管驱动力（毛细血管压力下降）。（摘要截短至250字）
