Krishnamoorthy R V
Indian J Physiol Pharmacol. 1975 Jul-Sep;19(3):121-8.
Abnormalities have been noticed in the phospholipid and cholesterol composition of the atrophied gastrocnemius muscle of frog denervated for 1 month. Cholesterol : phospholipid molar ratios in the muscle increased on denervation. Sphingomyelin and cardiolipin fractions increased in contrast to phosphatidyl choline, phosphatidyl serine and phosphatidyl ethanolamine in the sarcoplasmic reticulum (SR) of denervated muscle. Na-azide sensitive Ca2+ ATPase activity of the mitochondria did not alter whereas that of SR decreased on denervation. Phospholipase C digestion impaired the organelle Ca2+-ATPase activity. The above abnormalities in enzyme activities have been correlated to the changes in the lipid composition of the denervated muscle. On the basis of these changes it is discussed that the primary change in the muscle due to denervation is the change in the permeability of the membrane.
在失神经支配1个月的青蛙萎缩腓肠肌的磷脂和胆固醇组成中已发现异常。失神经支配后，肌肉中的胆固醇与磷脂摩尔比增加。与失神经支配肌肉肌浆网（SR）中的磷脂酰胆碱、磷脂酰丝氨酸和磷脂酰乙醇胺相比，鞘磷脂和心磷脂组分增加。线粒体的叠氮化钠敏感Ca2+ATP酶活性未改变，而失神经支配后SR的该活性降低。磷脂酶C消化损害了细胞器Ca2+-ATP酶活性。酶活性的上述异常与失神经支配肌肉的脂质组成变化相关。基于这些变化，讨论了失神经支配导致肌肉的主要变化是膜通透性的改变。
