Ruiz S, Perretta M, Pérez H
Laboratory of Neurophysiology and Biophysics, University of Chile, Santiago.
Int J Neurosci. 1992 Jul-Aug;65(1-4):161-6. doi: 10.3109/00207459209003288.
The effect of neonatal capsaicin treatment on chemo- and/or barosensory input to the medulla was studied in 35-40-day-old rats. By means of responses evoked in the nucleus tractus solitarius by stimulating the ipsilateral sinusal nerve, the excitability of slow-conducting carotid afferent fibers and the effect of substance P microinjection into the fourth ventricle were evaluated. Neonatal capsaicin resulted in reduced amplitude of the late component of the evoked responses, increased chronaxie values in the strength-duration paradigm, and increased sensitivity of evoked responses to the inhibitory effect of intracerebroventricular administered substance P. The results indicate that capsaicin given early in life leads to functional disturbances of chemo- and/or barosensory input to the nucleus tractus solitarius, involving both the slow-conducting primary afferents and the receptors for substance P of the second-order cells of the sensory pathway.
在35至40日龄大鼠中研究了新生期辣椒素处理对延髓化学和/或压力感受性传入的影响。通过刺激同侧窦神经在孤束核中诱发的反应，评估了慢传导颈动脉传入纤维的兴奋性以及向第四脑室内微量注射P物质的作用。新生期辣椒素导致诱发反应晚期成分的幅度降低、强度-时间曲线中的时值增加，以及诱发反应对脑室内注射P物质抑制作用的敏感性增加。结果表明，生命早期给予辣椒素会导致孤束核化学和/或压力感受性传入的功能紊乱，涉及慢传导初级传入纤维以及感觉通路二级细胞的P物质受体。
