Veiga M C, Tambeli C H, Santoa A C, José J L
Departamento de Ciências Fisiológicas, FOP UNICAMP.
Arch Latinoam Nutr. 1992 Dec;42(4):414-9.
The objective of this study was to verify if the diet protein level affects the genesis of the repair tissue in rats submitted to a poly-chloro-vinyl (PVC) sponge implantation, as well as to analyse the possible alterations in the synthesis of the mucopolysaccharides acids (glucosaminoglycans) by the histophotometry technique. Forty five Wistar weanling male rats, at 21 days of age, were divided into three experimental groups; the groups were fed diets al 6%, 15% and 40% protein level from casein source, during at 69 days period. The animals which received the low protein diet (6%) presented an inhibition in the evolution and maturation of the granulation tissue mainly in the 4th, 7th and 10th days after the sponge PVC implantation. It was also observed that there was less infiltration of the inflammatory cells, less fibroblasts proliferation, reduction of the collagen fibers synthesis, neovascularization decreased and an inhibition of the mucopolysaccharide acids synthesis.
本研究的目的是验证饮食蛋白质水平是否会影响接受聚氯乙烯（PVC）海绵植入的大鼠修复组织的形成，以及通过组织光度测定技术分析酸性粘多糖（糖胺聚糖）合成中可能的变化。45只21日龄的Wistar雄性断奶大鼠被分为三个实验组；在69天的时间里，给这些组喂食酪蛋白来源的蛋白质水平分别为6%、15%和40%的饮食。接受低蛋白饮食（6%）的动物在PVC海绵植入后的第4天、第7天和第10天，肉芽组织的演变和成熟受到抑制。还观察到炎症细胞浸润减少、成纤维细胞增殖减少、胶原纤维合成减少、新血管形成减少以及酸性粘多糖合成受到抑制。
