Wareing M, Greenwood S L, Taggart M J, Baker P N
Maternal and Fetal Health Research Centre, University of Manchester, St Mary's Hospital, Hathersage Road, M13 0JH, Manchester, UK.
Placenta. 2003 Aug;24(7):790-6. doi: 10.1016/s0143-4004(03)00108-5.
The control of the blood flow within the fetoplacental circulation is poorly understood despite the essential role of the placenta in pregnancy. Our aim was to assess the vasoactive responses of veins from the placental chorionic plate. Biopsies were obtained from term placentae from uncomplicated pregnancies. Small veins from the chorionic plate were dissected free from surrounding tissue and studied using parallel wire myography. Human placental chorionic plate veins developed maintained constrictions to the thromboxane-mimetic U46619. Endothelium-dependent agonists did not promote venous relaxation. However, NO donation with the endothelial-independent agent, sodium nitroprusside, elicited significant relaxation. Venous constriction to U46619 and relaxation to sodium nitroprusside were modified by adjustment of media oxygen tension and normalization parameters. Human placental chorionic plate veins respond to vasoactive agents and may play a role in the control of the blood flow in the fetoplacental circulation.
尽管胎盘在妊娠中起着至关重要的作用，但人们对胎儿-胎盘循环内血流的控制仍知之甚少。我们的目的是评估胎盘绒毛膜板静脉的血管活性反应。从无并发症妊娠的足月胎盘中获取活检组织。从绒毛膜板分离出小静脉，使其与周围组织分离，并使用平行钢丝肌动描记法进行研究。人胎盘绒毛膜板静脉对血栓素模拟物U46619产生持续收缩。内皮依赖性激动剂不会促进静脉舒张。然而，使用非内皮依赖性药物硝普钠给予一氧化氮可引起显著舒张。通过调整培养基氧张力和标准化参数，可改变静脉对U46619的收缩和对硝普钠的舒张。人胎盘绒毛膜板静脉对血管活性药物有反应，可能在胎儿-胎盘循环血流控制中发挥作用。
