Brodbelt A R, Stoodley M A
Prince of Wales Medical Research Institute, University of New South Wales, NSW, Randwick, Australia.
J Clin Neurosci. 2003 Jul;10(4):401-8. doi: 10.1016/s0967-5868(02)00326-0.
More than a quarter of spinal cord injured patients develop syringes and many of these patients suffer progressive neurological deficits as a result of cyst enlargement. The mechanism of initial cyst formation and progressive enlargement are unknown, although arachnoiditis and persisting cord compression with disturbance of cerebrospinal fluid flow appear to be important aetiological factors. Current treatment options include correction of bony deformity, decompression of the spinal cord, division of adhesions, and shunting. Long-term improvement occurs in fewer than half of patients treated. Imaging evidence of a reduction in syrinx size following treatment does not guarantee symptomatic resolution or even prevention of further neurological loss. A better understanding of the causal mechanisms of syringomyelia is required to develop more effective therapy.
超过四分之一的脊髓损伤患者会形成脊髓空洞，其中许多患者由于囊肿扩大而出现进行性神经功能缺损。尽管蛛网膜炎和脑脊液流动紊乱导致的持续性脊髓压迫似乎是重要的病因因素，但初始囊肿形成和进行性扩大的机制尚不清楚。目前的治疗选择包括矫正骨骼畸形、脊髓减压、粘连分离和分流。接受治疗的患者中，不到一半能实现长期改善。治疗后脊髓空洞大小缩小的影像学证据并不能保证症状缓解，甚至不能预防进一步的神经功能丧失。需要更好地了解脊髓空洞症的病因机制，以开发更有效的治疗方法。
