Kashaw Sushil K, Rathi Lalit, Mishra Pradeep, Saxena Anil K
Medicinal Chemistry Division, Central Drug Research Institute, Lucknow 226001, India.
Bioorg Med Chem Lett. 2003 Aug 4;13(15):2481-4. doi: 10.1016/s0960-894x(03)00491-8.
Pharmacophoric mapping based on 3D-QSAR studies is performed on sixteen cyclic ureidobenzenesulfonamides for their beta(3)-adrenergic receptor agonistic activity. The best 3D-QSAR model (with r(2)=0.877) which described the properties and distributions of 5-biophoric and 2-secondary biophoric sites, showed a good correlation between the observed and predicted activity both in training and test.
