针对人类小细胞肺癌的免疫毒素
Immunotoxins to human small-cell lung cancer.
作者信息
Wawrzynczak E J, Derbyshire E J
机构信息
Drug Targeting Laboratory, Institute of Cancer Research, Sutton, Surrey, UK.
出版信息
Cell Biophys. 1992 Aug-Dec;21(1-3):13-23. doi: 10.1007/BF02789474.
PMID:1285325
Abstract
Ricin A chain ITs directed against a variety of the common cell-surface antigens associated with SCLC exerted selective toxic effects on SCLC cell lines. The potency of the cytotoxic effects matched or exceeded that previously reported for ricin A chain ITs directed against identical or similar antigens on other types of carcinoma, suggesting that SCLC may be uniquely sensitive to this type of IT.
摘要
蓖麻毒素A链免疫毒素（ITs）针对与小细胞肺癌（SCLC）相关的多种常见细胞表面抗原，对SCLC细胞系产生了选择性毒性作用。细胞毒性作用的效力与先前报道的针对其他类型癌症上相同或相似抗原的蓖麻毒素A链免疫毒素相当或更强，这表明SCLC可能对这类免疫毒素具有独特的敏感性。
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