信号识别颗粒的结构、功能及进化
Structure, function and evolution of the signal recognition particle.
作者信息
Nagai Kiyoshi, Oubridge Chris, Kuglstatter Andreas, Menichelli Elena, Isel Catherine, Jovine Luca
机构信息
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.
出版信息
EMBO J. 2003 Jul 15;22(14):3479-85. doi: 10.1093/emboj/cdg337.
Abstract
The signal recognition particle (SRP) is a ribonucleoprotein particle essential for the targeting of signal peptide-bearing proteins to the prokaryotic plasma membrane or the eukaryotic endoplasmic reticulum membrane for secretion or membrane insertion. SRP binds to the signal peptide emerging from the exit site of the ribosome and forms a ribosome nascent chain (RNC)-SRP complex. The RNC-SRP complex then docks in a GTP-dependent manner with a membrane-anchored SRP receptor and the protein is translocated across or integrated into the membrane through a channel called the translocon. Recently considerable progress has been made in understanding the architecture and function of SRP.
摘要
信号识别颗粒（SRP）是一种核糖核蛋白颗粒，对于将携带信号肽的蛋白质靶向到原核细胞质膜或真核内质网膜以进行分泌或膜插入至关重要。SRP与从核糖体出口位点出现的信号肽结合，形成核糖体新生链（RNC）-SRP复合物。然后，RNC-SRP复合物以GTP依赖的方式与膜锚定的SRP受体对接，蛋白质通过称为易位子的通道跨膜转运或整合到膜中。最近，在理解SRP的结构和功能方面取得了相当大的进展。
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