Molimard M, Lebeau B
Service de Pneumologie, Hôpital Saint-Antoine, Paris.
Rev Med Interne. 1992 Nov;13(6):441-2.
A case of squamous cell bronchial carcinoma developed 8 years after treatment of a small cell carcinoma is reported. Three hypotheses may be put forward to explain this sequence of events: either a squamous cell line was selected from within an initially mixed tumour, or the small cell carcinoma differentiated into a squamous cell carcinoma, or a second primary tumour developed independently. All this is purely speculative, but the long doubling time implied by the first two hypotheses would be in favour of a second primary tumour.
报告了1例小细胞癌治疗8年后发生的支气管鳞状细胞癌病例。对于这一系列事件，可以提出三种假说进行解释：要么是从最初的混合性肿瘤中选出了鳞状细胞系，要么是小细胞癌分化成了鳞状细胞癌，要么是独立发生了第二个原发性肿瘤。所有这些都纯属推测，但前两种假说所暗示的较长倍增时间支持第二个原发性肿瘤的观点。
