转录调控与动物多样性

Transcription regulation and animal diversity.

作者信息

Levine Michael, Tjian Robert

机构信息

Department of Molecular and Cell Biology, Division of Genetics and Development, Center for Integrative Genomics, University of California, Berkeley, 401 Barker Hall, Berkeley, California 94720, USA.

出版信息

Nature. 2003 Jul 10;424(6945):147-51. doi: 10.1038/nature01763.

DOI:10.1038/nature01763

PMID:12853946

Abstract

Whole-genome sequence assemblies are now available for seven different animals, including nematode worms, mice and humans. Comparative genome analyses reveal a surprising constancy in genetic content: vertebrate genomes have only about twice the number of genes that invertebrate genomes have, and the increase is primarily due to the duplication of existing genes rather than the invention of new ones. How, then, has evolutionary diversity arisen? Emerging evidence suggests that organismal complexity arises from progressively more elaborate regulation of gene expression.

摘要

目前已经获得了包括线虫、小鼠和人类在内的七种不同动物的全基因组序列组装。比较基因组分析揭示了遗传内容中惊人的稳定性：脊椎动物基因组的基因数量仅约为无脊椎动物基因组的两倍，而且这种增加主要是由于现有基因的复制而非新基因的产生。那么，进化多样性是如何产生的呢？新出现的证据表明，生物体的复杂性源于对基因表达越来越精细的调控。