van Steensel Bas
the Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
Nat Genet. 2005 Jun;37 Suppl:S18-24. doi: 10.1038/ng1559.
The highly coordinated expression of thousands of genes in an organism is regulated by the concerted action of hundreds of transcription factors and chromatin proteins, as well as by epigenetic mechanisms. Understanding the architecture of these vastly complex regulatory networks is one of the main challenges in the postgenomic era. New microarray-based techniques have become available for the genome-wide mapping of in vivo protein-DNA interactions and epigenetic marks. Data sets obtained with these techniques begin to offer the first comprehensive views of genetic and epigenetic regulatory networks.
生物体中数千个基因的高度协调表达是由数百种转录因子和染色质蛋白的协同作用以及表观遗传机制调控的。理解这些极其复杂的调控网络的结构是后基因组时代的主要挑战之一。基于微阵列的新技术已可用于全基因组范围内体内蛋白质 - DNA相互作用和表观遗传标记的图谱绘制。通过这些技术获得的数据集开始提供遗传和表观遗传调控网络的首批全面视图。
