Słomka M, Szczerbo-trojanowska M, Celiński K, Skrzydło-Radomańska B
Katedra i Klinika Gastroenterologii, Akademia Medyczna w Lublinie.
Ann Univ Mariae Curie Sklodowska Med. 1991;46:81-7.
The experiments were performed in the healthy mongrel dogs aged 5 to 8 years whose body weight ranged from 10-20 kg. Just after the coeliac arteriography the hepatic artery was embolized. The dogs were divided into 2 groups because of the application of two different embolizing materials. Spongostan was used as the embolizing material in group I consisting of 7 dogs. In group II consisting of 5 dogs the embolizing material was absolute ethyl alcohol with urogranic acid. The symptoms of the postembolization syndrome were observed in all dogs after the embolization for 1-5 days. In most dogs the transient increase of the aminotransferase activity was observed while the results of thymol turbidity test and bilirubin levels in serum were not significantly changed. In dogs of group II the clinical picture after the embolization was clearly more severe. The anatomo- and histopathological examinations in dogs after the hepatic artery embolization were carried out. In group I no hepatic changes were found macroscopically. In the histopathological studies of liver the numerous, tiny foci of coagulative necrosis with the resorptive reactions were noticed. In group II multifocal deliquescent necrosis in the liver, numerous, small perivascular and extravascular foci of coagulative-deliquescent necrosis with the inflammatory and the resorptive reactions were noted.
实验在5至8岁、体重10至20千克的健康杂种犬身上进行。在腹腔动脉造影后立即对肝动脉进行栓塞。由于使用了两种不同的栓塞材料，将犬分为两组。第一组7只犬使用明胶海绵作为栓塞材料。第二组5只犬使用无水乙醇与尿酸的混合液作为栓塞材料。栓塞后1至5天观察所有犬的栓塞后综合征症状。大多数犬观察到转氨酶活性短暂升高，而麝香草酚浊度试验结果和血清胆红素水平无明显变化。第二组犬栓塞后的临床表现明显更严重。对肝动脉栓塞后的犬进行了解剖学和组织病理学检查。第一组在宏观上未发现肝脏变化。在肝脏组织病理学研究中，发现了许多微小的凝固性坏死灶及吸收反应。第二组肝脏出现多灶性液化性坏死，有许多小的血管周围和血管外凝固性 - 液化性坏死灶，并伴有炎症和吸收反应。
