特应性皮炎皮损皮肤中P物质水平降低。

Substance P levels are decreased in lesional skin of atopic dermatitis.

作者信息

Fantini F, Pincelli C, Romualdi P, Donatini A, Giannetti A

机构信息

Institute of Dermatology, University of Modena, Italy.

出版信息

Exp Dermatol. 1992 Oct;1(3):127-8. doi: 10.1111/j.1600-0625.1992.tb00003.x.

DOI:10.1111/j.1600-0625.1992.tb00003.x

PMID:1285408

Abstract

There is increasing evidence that neuropeptides (NP) such as substance P (SP) and vasoactive intestinal polypeptide (VIP) are involved in the pathogenesis of atopic dermatitis (AD). Vasoactive intestinal polypeptide levels were found to be significantly elevated in lesional skin of AD as compared to controls. We evaluated by radioimmunoassay the SP content in whole skin homogenates from chronic lichenified lesions of patients with AD. The levels of SP were significantly decreased in lesional skin from AD patients as compared to control skin (0.25 +/- 0.03 vs. 0.97 +/- 0.24 pmol/g tissue, p < 0.01). The diminished SP levels as opposed to increased VIP concentrations could be consistent with different roles of these NP as modulatory agents in the mechanisms associated with AD.

摘要

越来越多的证据表明，诸如P物质（SP）和血管活性肠肽（VIP）等神经肽（NP）参与了特应性皮炎（AD）的发病机制。与对照组相比，发现AD患者皮损皮肤中的血管活性肠肽水平显著升高。我们通过放射免疫测定法评估了AD患者慢性苔藓化皮损全皮肤匀浆中的SP含量。与对照皮肤相比，AD患者皮损皮肤中的SP水平显著降低（0.25±0.03对0.97±0.24 pmol/g组织，p<0.01）。与VIP浓度升高相反，SP水平降低可能与这些NP作为AD相关机制中的调节剂的不同作用一致。