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[小儿肾移植的麻醉管理:15例10岁以下患儿的回顾]

[Anesthetic management of pediatric renal transplantation: a review of 15 cases under the age of 10 years].

作者信息

Yamamoto Rie, Nakai Rie, Nagasawa Mika, Terada Takashi, Maehara Yasuhiro, Sasaki Junji, Kikuchi Hirosato

机构信息

First Department of Anesthesiology, Toho University School of Medicine, Tokyo 143-8541.

出版信息

Masui. 2003 Jun;52(6):631-5.

Abstract

BACKGROUND

In pediatric renal transplantation, an adult kidney is transplanted to a small child and it may cause severe cardiovascular insufficiency.

METHODS

The anesthetic management of 15 pediatric recipients younger than 10 years, undergoing living-related renal transplantation were analyzed retrospectively.

RESULTS

Before the operation, 3 of 15 patients were receiving hemodialysis, and the others were receiving peritoneal dialysis. Isoflurane was used for the anesthetic maintenance in most of cases. Arterial and central venous pressures were monitored invasively in all cases. Pulmonary arterial catheters and transesophageal echocardiography were used in some patients with cardiac complications. For intraoperative fluid management, a total volume of 18 ml.kg-1.h-1 (mean) was infused, which included approximately 8 ml.kg-1.h-1 of crystalloid, 7 ml.kg-1.h-1 of fresh frozen plasma, and 2 ml.kg-1.h-1 of washed red blood cells. Dopamine 1-7 micrograms.kg-1.min-1 and human atrial natriuretic peptide (hANP) 0.05-0.1 microgram.kg-1.min-1 were administered as diuretics. None of 15 patients developed severe cardiovascular insufficiency of poor diuresis.

CONCLUSIONS

Cardiovascular stability and good function of the transplanted kidney were maintained by appropriate monitoring and continuous intravenous infusion of dopamine and hANP. It is important to infuse enough volume of fluid and blood before recanalization.

摘要

背景

在小儿肾移植中,将成人肾脏移植给小儿可能会导致严重的心血管功能不全。

方法

回顾性分析15例年龄小于10岁的亲属活体肾移植小儿受者的麻醉管理情况。

结果

术前,15例患者中有3例接受血液透析,其余接受腹膜透析。大多数病例使用异氟烷进行麻醉维持。所有病例均有创监测动脉压和中心静脉压。部分有心脏并发症的患者使用了肺动脉导管和经食管超声心动图。术中液体管理方面,平均每小时每千克体重输注总量为18毫升,其中包括约每小时每千克体重8毫升的晶体液、7毫升的新鲜冰冻血浆和2毫升的洗涤红细胞。使用多巴胺1 - 7微克·每千克体重·每分钟和人心房利钠肽(hANP)0.05 - 0.1微克·每千克体重·每分钟作为利尿剂。15例患者均未出现严重的心血管功能不全或利尿不良情况。

结论

通过适当的监测以及持续静脉输注多巴胺和hANP,维持了心血管稳定性和移植肾的良好功能。在血管再通前输注足够量的液体和血液很重要。

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