Mellin K B
Augenklinik, Universitätsklinikums der Gesamthochschule, Essen.
Zentralbl Chir. 1992;117(12):695-700.
In contrast to organ transplantations corneal grafts are tissue transplantations with the advantage of a minority of immune stimulating cells. The incidence of allograft rejections is greater in penetrating grafts than in lamellar grafts because of endothelial immune reactions. The decompensation of the graft is caused by the damage of the endothelial layer. The influence of HLA-A, -B and -DR matching is proven in case of vascularised cornea or of repeated perforating keratoplasty. The introduction of the immunosuppressive therapy with Ciclosporin A was successful in maintaining a clear graft.
与器官移植不同，角膜移植是组织移植，其优势在于免疫刺激细胞较少。由于内皮免疫反应，穿透性移植中同种异体移植排斥的发生率高于板层移植。移植失代偿是由内皮层损伤引起的。在血管化角膜或重复穿透性角膜移植的情况下，已证实HLA - A、- B和 - DR配型的影响。使用环孢素A进行免疫抑制治疗成功地维持了移植角膜的透明。
