Anlar Omer, Kisli Mesude, Tombul Temel, Ozbek Hanefi
Department of Neurology, University of Yuzuncu Yil, Van, Turkey.
Int J Neurosci. 2003 Apr;113(4):483-9. doi: 10.1080/00207450390162236.
Magnetic resonance imaging (MRI) is important in the diagnosis of and follow-up for the treatment of multiple sclerosis (MS); evoked potentials may be important if MRI is normal or cannot be performed. We assessed serial visual evoked potentials (VEPs) and cranial MRI in a group of clinically relapsing-remitting multiple sclerosis (N = 15) treated with interferon beta-lb (INFB-1b) and in normal subjects (N = 15). The investigations were done 1 week before INFB-lb therapy, 1 year later (N = 15), and 2 years later (N = 10). VEPs were abnormal in most of the patients; MRIs were abnormal in all patients. We used P100 latency as an electrophysiological index for the progress of illness. There were significant differences in VEPs between the beginning and ending of the interferon treatment. We concluded that VEPs would be a reliable index for following up the progress of MS under interferon therapy.
磁共振成像（MRI）在多发性硬化症（MS）的诊断及治疗随访中具有重要作用；如果MRI结果正常或无法进行MRI检查，诱发电位可能具有重要意义。我们评估了一组接受β-1b干扰素（INFB-1b）治疗的临床复发缓解型多发性硬化症患者（N = 15）以及正常受试者（N = 15）的系列视觉诱发电位（VEP）和头颅MRI。在INFB-1b治疗前1周、1年后（N = 15）以及2年后（N = 10）进行了相关检查。大多数患者的VEP异常；所有患者的MRI均异常。我们将P100潜伏期作为疾病进展的电生理指标。干扰素治疗开始和结束时VEP存在显著差异。我们得出结论，VEP将是干扰素治疗下MS病情随访的可靠指标。
