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[墨西哥国家心脏病学研究所伊格纳西奥·查韦斯分院扩张型心肌病患者中克氏锥虫抗体的发生率]

[The incidence of Trypanosoma cruzi antibodies in patients with dilated myocardiopathy at the Instituto Nacional de Cardiología Ignacio Chávez].

作者信息

Rodas A, Toro S, Ramos A, Monteón V M, Reyes P A

机构信息

Instituto Nacional de Cardiología Ignacio Chávez (INCICH), México, D.F.

出版信息

Arch Inst Cardiol Mex. 1992 Nov-Dec;62(6):541-5.

PMID:1285664
Abstract

Our objective was to measure the incidence of humoral immune response against Trypanosoma cruzi among patients with a definitive diagnosis of dilated cardiomyopathy at the Instituto Nacional de Cardiología "I. Chávez" over a year. Thirty seven patients were collected, 15 of them (40%) had antibodies against T. cruzi in two different tests, indirect immunofluorescence and ELISA, the presence of IgG antibody was confirmed through Western blot. There was not differences in clinical picture of cardiomyopathy nor on paraclinical studies. However, there was a significant difference in regard socio economical indexes between the group with positive anti T. cruzi antibodies. They had a predominant rural origin, poor housing and were aware of the vector bug. Also they recalled primary infection in their childhood--American trypanosomiasis could be on important etiologic factor for dilated cardiomyopathy in our country.

摘要

我们的目标是在一年时间里,对国立心脏病学研究所“I. Chávez”确诊为扩张型心肌病的患者中,针对克氏锥虫的体液免疫反应发生率进行测量。收集了37例患者,其中15例(40%)在间接免疫荧光和酶联免疫吸附测定这两种不同检测中检测出抗克氏锥虫抗体,通过蛋白质印迹法确认了IgG抗体的存在。心肌病的临床表现和辅助检查均无差异。然而,抗克氏锥虫抗体呈阳性的组在社会经济指标方面存在显著差异。他们主要来自农村,住房条件差,知晓传播媒介臭虫。此外,他们回忆起童年时有过初次感染——美洲锥虫病可能是我国扩张型心肌病的一个重要病因。

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