Hashimoto Yasushi, Murata Akira, Mikami Masashi, Nakamura Seiichi, Yamanaka Eiichi, Kudoh Shoji
Department of Respiratory Medicine, Tokyo Metropolitan Hiro-o General Hospital, Tokyo, Japan.
Respirology. 2003 Mar;8(1):45-51. doi: 10.1046/j.1440-1843.2003.00432.x.
There have been several reports regarding the role of airway mucus in cough sound generation, but the properties of the mucus that influence cough sound generation remain unclear. The aim of this study was to elucidate the influence of the rheological properties of airway mucus on cough sound generation.
The acoustic properties of voluntary cough sounds from 15 patients with chronic productive cough and nine controls with dry cough were analyzed by dividing the energy envelope of the sounds into three phases and computing the root mean square values and the duration of each phase as a proportion of the total cough duration. The rheological properties of the airway mucus (yield value, ciliary transportability and spinability) were also measured. Differences between productive and dry cough sounds, and correlations between the acoustic properties of cough sounds and the rheological properties of the airway mucus, were analyzed.
The acoustic properties of productive and dry cough sounds differed significantly (P < 0.05). The acoustic properties of second phase cough sounds correlated significantly with the yield value and ciliary transportability of the airway mucus (P < 0.05).
The rheological properties of the airway mucus influenced cough sound generation.
已有多篇关于气道黏液在咳嗽声音产生中作用的报道，但影响咳嗽声音产生的黏液特性仍不明确。本研究的目的是阐明气道黏液的流变学特性对咳嗽声音产生的影响。
通过将声音的能量包络分为三个阶段，并计算每个阶段的均方根值和持续时间占总咳嗽持续时间的比例，分析了15例慢性咳痰性咳嗽患者和9例干咳对照者的自主咳嗽声音的声学特性。还测量了气道黏液的流变学特性（屈服值、纤毛运输能力和可纺性）。分析了咳痰性咳嗽和干咳声音之间的差异，以及咳嗽声音的声学特性与气道黏液流变学特性之间的相关性。
咳痰性咳嗽和干咳声音的声学特性有显著差异（P < 0.05）。第二阶段咳嗽声音的声学特性与气道黏液的屈服值和纤毛运输能力显著相关（P < 0.05）。
气道黏液的流变学特性影响咳嗽声音的产生。
