Gholap S, Kar A
Thyroid Research Unit, School of Life Sciences, D. A. University, Khandwa Road, Indore, India.
Pharmazie. 2003 Jun;58(6):413-5.
The efficacy of Inula racemosa (root) and Gymnema sylvestre (leaf) extracts either alone or in combination was evaluated in the amelioration of corticosteroid-induced hyperglycaemia in mice. Simultaneously thyroid hormone levels were estimated by radio-immunoassay (RIA) in order to ascertain whether the effects are mediated through thyroid hormones or not. While the corticosteroid (dexamethasone) administration increased the serum glucose concentration, it decreased serum concentrations of the thyroid hormones, thyroxine (T4) and triiodothyronine (T3). Administration of the two plant extracts either alone or in combination decreased the serum glucose concentration in dexamethasone induced hyperglycaemic animals. However, the administration of Inula racemosa and Gymnema sylvestre extracts in combination proved to be more effective than the individual extracts. These effects were comparable to a standard corticosteroid-inhibiting drug, ketoconazole. As no marked changes in thyroid hormone concentrations were observed by the administration of any of the plant extracts in dexamethasone treated animals, it is further suggested that these plant extracts may not prove to be effective in thyroid hormone mediated type II diabetes, but for steroid induced diabetes.
对绵头旋覆花（根）提取物和匙羹藤（叶）提取物单独或联合使用在改善小鼠皮质类固醇诱导的高血糖方面的功效进行了评估。同时，通过放射免疫分析（RIA）测定甲状腺激素水平，以确定这些作用是否通过甲状腺激素介导。虽然给予皮质类固醇（地塞米松）会增加血清葡萄糖浓度，但会降低甲状腺激素、甲状腺素（T4）和三碘甲状腺原氨酸（T3）的血清浓度。单独或联合给予两种植物提取物均可降低地塞米松诱导的高血糖动物的血清葡萄糖浓度。然而，事实证明，联合给予绵头旋覆花和匙羹藤提取物比单独给予提取物更有效。这些作用与标准的皮质类固醇抑制药物酮康唑相当。由于在接受地塞米松治疗的动物中给予任何一种植物提取物后，均未观察到甲状腺激素浓度有明显变化，因此进一步表明，这些植物提取物可能对甲状腺激素介导的II型糖尿病无效，但对类固醇诱导的糖尿病有效。
