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1
Glycoprotein G isoforms from some alphaherpesviruses function as broad-spectrum chemokine binding proteins.一些甲型疱疹病毒的糖蛋白G亚型可作为广谱趋化因子结合蛋白发挥作用。
EMBO J. 2003 Feb 17;22(4):833-46. doi: 10.1093/emboj/cdg092.
2
Viral mimicry of cytokines, chemokines and their receptors.病毒对细胞因子、趋化因子及其受体的模拟
Nat Rev Immunol. 2003 Jan;3(1):36-50. doi: 10.1038/nri980.
3
Structural basis of chemokine sequestration by a herpesvirus decoy receptor.疱疹病毒诱饵受体隔离趋化因子的结构基础
Cell. 2002 Nov 1;111(3):343-56. doi: 10.1016/s0092-8674(02)01007-3.
4
Critical role for a high-affinity chemokine-binding protein in gamma-herpesvirus-induced lethal meningitis.高亲和力趋化因子结合蛋白在γ-疱疹病毒诱导的致死性脑膜炎中的关键作用
J Clin Invest. 2002 Apr;109(7):905-14. doi: 10.1172/JCI14358.
5
The viral CC chemokine-binding protein vCCI inhibits monocyte chemoattractant protein-1 activity by masking its CCR2B-binding site.病毒CC趋化因子结合蛋白vCCI通过掩盖单核细胞趋化蛋白-1的CCR2B结合位点来抑制其活性。
J Biol Chem. 2001 Nov 16;276(46):43270-6. doi: 10.1074/jbc.M106305200. Epub 2001 Sep 10.
6
A secreted chemokine binding protein encoded by murine gammaherpesvirus-68 is necessary for the establishment of a normal latent load.鼠γ-疱疹病毒68编码的一种分泌型趋化因子结合蛋白对于建立正常的潜伏感染负荷是必需的。
J Exp Med. 2001 Aug 6;194(3):301-12. doi: 10.1084/jem.194.3.301.
7
Molecular determinants for CC-chemokine recognition by a poxvirus CC-chemokine inhibitor.痘病毒CC趋化因子抑制剂识别CC趋化因子的分子决定因素。
Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9008-13. doi: 10.1073/pnas.171069398. Epub 2001 Jul 24.
8
Viral exploitation and subversion of the immune system through chemokine mimicry.病毒通过趋化因子模拟对免疫系统的利用与颠覆
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9
Identification of a gammaherpesvirus selective chemokine binding protein that inhibits chemokine action.一种抑制趋化因子作用的γ疱疹病毒选择性趋化因子结合蛋白的鉴定。
J Virol. 2000 Aug;74(15):6741-7. doi: 10.1128/jvi.74.15.6741-6747.2000.
10
A broad spectrum secreted chemokine binding protein encoded by a herpesvirus.一种由疱疹病毒编码的广谱分泌型趋化因子结合蛋白。
J Exp Med. 2000 Feb 7;191(3):573-8. doi: 10.1084/jem.191.3.573.

γ疱疹病毒趋化因子结合蛋白与CXCL8的N端结合。

The gammaherpesvirus chemokine binding protein binds to the N terminus of CXCL8.

作者信息

Webb Louise M C, Clark-Lewis Ian, Alcami Antonio

机构信息

Department of Medicine, Division of Virology, University of Cambridge, Cambridge, United Kingdom.

出版信息

J Virol. 2003 Aug;77(15):8588-92. doi: 10.1128/jvi.77.15.8588-8592.2003.

DOI:10.1128/jvi.77.15.8588-8592.2003
PMID:12857930
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC165246/
Abstract

Viruses encode proteins that disrupt chemokine responses. The murine gammaherpesvirus 68 gene M3 encodes a chemokine binding protein (vCKBP-3) which has no sequence similarity to chemokine receptors but inhibits chemokine receptor binding and activity. We have used a panel of CXCL8 analogs to identify the structural requirements for CXCL8 to bind to vCKBP-3 in a scintillation proximity assay. Our data suggest that vCKBP-3 acts by mimicking the binding of chemokine receptors to CXCL8.

摘要

病毒编码可破坏趋化因子反应的蛋白质。小鼠γ疱疹病毒68基因M3编码一种趋化因子结合蛋白（vCKBP - 3），它与趋化因子受体没有序列相似性，但能抑制趋化因子受体的结合和活性。我们使用了一组CXCL8类似物，通过闪烁邻近分析来确定CXCL8与vCKBP - 3结合的结构要求。我们的数据表明，vCKBP - 3通过模拟趋化因子受体与CXCL8的结合来发挥作用。