Cohen Philip L
University of Pennsylvania, Philadelphia, PA, USA.
Immunol Res. 2003;27(2-3):179-84. doi: 10.1385/IR:27:2-3:179.
Systemic autoimmunity is an important clinical problem, offering a window into fundamental questions of self-nonself tolerance. We have used cellular immunology, serology, and immunopathology to approach several spontaneous mouse models. Although much remains to be done, a picture is emerging of pathological antigen-driven immune responses to self nuclear antigens, highly dependent on multiple genes, and susceptible to abnormalities of apoptosis.
全身性自身免疫是一个重要的临床问题，为深入了解自身与非自身耐受的基本问题提供了一个窗口。我们运用细胞免疫学、血清学和免疫病理学方法研究了几种自发小鼠模型。尽管仍有许多工作要做，但一幅关于针对自身核抗原的病理性抗原驱动免疫反应的图景正在浮现，这种反应高度依赖多个基因，且易受细胞凋亡异常的影响。
