Bitzer M, Lauer U M
Abteilung Innere Medizin I, Medizinische Universitätsklinik, Tübingen.
Z Gastroenterol. 2003 Jul;41(7):667-74. doi: 10.1055/s-2003-40543.
Gastroenterological oncology requires new strategies with new mechanisms of action and without cross-resistance to currently available treatment regimes. Virotherapy which is based on the employment of replication-competent viral vectors exhibiting strong oncolytic properties is such an approach currently under preclinical/clinical investigation. Techniques of molecular virology are required for further improvement of current vectors, particularly with respect to oncolytic activity, tumour selectivity, tumour spread capacity, and safety.
胃肠肿瘤学需要具有新作用机制且对现有治疗方案无交叉耐药性的新策略。基于使用具有强大溶瘤特性的复制型病毒载体的病毒疗法是目前正在进行临床前/临床研究的一种方法。分子病毒学技术对于进一步改进当前载体是必需的，特别是在溶瘤活性、肿瘤选择性、肿瘤扩散能力和安全性方面。
