Hengel Hartmut, Masihi K Noel
Robert Koch Institute, Nordufer 20, D-13353 Berlin, Germany.
Int Immunopharmacol. 2003 Aug;3(8):1159-67. doi: 10.1016/S1567-5769(03)00028-6.
Combating pathogenic organisms by combinatorial approaches involving appropriate immune response molecules and antimicrobial drugs represents a progessively more apparent and successful therapeutic paradigm for the treatment of acute and chronic persistent infectious diseases. This review explores areas of current innovation and provides an update of the present state of knowledge concerning combination of chemotherapy with several immune-based interventions in infections. In the future, a better understanding of microbial immune modulation and evasion may continue to open new avenues of inquiry and carefully targeted application of adjunctive immunotherapies.
通过涉及适当免疫反应分子和抗菌药物的组合方法来对抗致病生物，对于治疗急性和慢性持续性传染病而言，正日益成为一种更为明显且成功的治疗模式。本综述探讨了当前的创新领域，并更新了有关化疗与几种基于免疫的感染干预措施联合应用的现有知识状态。未来，对微生物免疫调节和逃避机制的更深入理解可能会继续开辟新的研究途径，并谨慎地针对性应用辅助免疫疗法。
