Chaim Walter, Horowitz Shulamith, David Juri Bar, Ingel Frida, Evinson Bela, Mazor Moshe
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, PO Box 151, Beer-Sheva 84101, Israel.
Eur J Obstet Gynecol Reprod Biol. 2003 Aug 15;109(2):145-8. doi: 10.1016/s0301-2115(03)00007-1.
Investigation of the clinical significance of Ureaplasma urealyticum and its biovars in the development of postpartum endometritis.
Cervical swabs were cultured for U. urealyticum in women presenting endometritis. The positive U. urealyticum cultures (>10(5) cfu/ml) (study group) were compared with those from women without endometritis (control group). Anti-Ureaplasma antibodies were measured and U. urealyticum biovars were determined by polymerase chain reaction.
There was no difference between the prevalence of U. urealyticum in the cervical swabs of both groups, however, the number of cfu per culture, showed a significant difference between study and control groups. Out of the culture positive endometritis patients 39% (26/67) had >10(5) cfu/ml compared to 17% of control patients (5/30) P=0.03. No significant disparity between both the groups was found in the prevalence of the parvo biovar (77% versus 71.5%, respectively). The difference in anti-Ureaplasma antibodies reached no statistical significance (30% versus 18% in study and control groups, respectively).
The significant difference in U. urealyticum culture cfu between both groups suggests that U. urealyticum may play a role in the etiology of this infection. This involvement is dependent not only on the presence or absence of U. urealyticum in the culture, but on its colonization rate in the cervix (>10(5) cfu/ml).
研究解脲脲原体及其生物变种在产后子宫内膜炎发生发展中的临床意义。
对出现子宫内膜炎的女性进行宫颈拭子培养以检测解脲脲原体。将解脲脲原体培养阳性（>10⁵ cfu/ml）的女性（研究组）与未患子宫内膜炎的女性（对照组）进行比较。检测抗解脲脲原体抗体，并通过聚合酶链反应确定解脲脲原体生物变种。
两组宫颈拭子中解脲脲原体的患病率无差异，然而，每次培养的cfu数量在研究组和对照组之间存在显著差异。培养阳性的子宫内膜炎患者中，39%（26/67）的cfu>10⁵/ml，而对照组患者为17%（5/30），P = 0.03。两组在细小生物变种的患病率上未发现显著差异（分别为77%和71.5%）。抗解脲脲原体抗体的差异无统计学意义（研究组和对照组分别为30%和18%）。
两组之间解脲脲原体培养cfu的显著差异表明，解脲脲原体可能在这种感染的病因学中起作用。这种关联不仅取决于培养物中解脲脲原体的有无，还取决于其在宫颈中的定植率（>10⁵ cfu/ml）。
