Kapitola J, Schreiber V, Andrle J, Kubícková J
Laboratory for Endocrinology and Metabolism, First Faculty of Medicine, Charles University, Prague.
Physiol Res. 1992;41(5):393-8.
In three experiments (2 on females, 1 on males), we determined the blood flow in the tibia and the distal part of the femur, together with cardiac output (by means of 85Sr-microspheres), tibial bone density and tibial ash weight related to bone volume. We found that 1) the bone blood flow always fell significantly after oestradiol benzoate, 2) no change occurred after norethisterone in doses corresponding to those of oestradiol benzoate, but the blood flow showed a tendency to fall after doses one order higher (it decreased significantly in one case only), 3) the density of the tibia and tibial ash weight related to bone volume rose nonsignificantly after oestradiol benzoate, but fell (mostly statistically significantly) after norethisterone. The lowering of the bone mineral indexes in rat bones after norethisterone is a surprising and potentially significant finding requiring further verification.
在三项实验中（两项针对雌性，一项针对雄性），我们测定了胫骨和股骨远端的血流量，同时通过85锶微球法测定了心输出量、胫骨骨密度以及与骨体积相关的胫骨骨灰重量。我们发现：1）苯甲酸雌二醇处理后，骨血流量总是显著下降；2）炔诺酮剂量与苯甲酸雌二醇相当时，血流量无变化，但剂量高一个数量级时，血流量有下降趋势（仅在一例中显著下降）；3）苯甲酸雌二醇处理后，胫骨密度和与骨体积相关的胫骨骨灰重量略有升高，但炔诺酮处理后则下降（大多具有统计学意义）。炔诺酮处理后大鼠骨骼中骨矿物质指标的降低是一个令人惊讶且可能具有重要意义的发现，需要进一步验证。
