Schmachtenberg Oliver, Diaz Javier, Bacigalupo Juan
Centro de Neurociencias de Valparaiso (CNV), Facultad de Ciencias, Universidad de Valparaiso, Avda. Gran Bretania 1111, Valparaíso, Chile.
Brain Res. 2003 Aug 1;980(1):146-50. doi: 10.1016/s0006-8993(03)02990-1.
Nitric oxide (NO) is a putative neuronal messenger in the olfactory epithelium. We analysed the electrical responses of rat olfactory receptor neurones to NO stimulation in the whole-cell patch clamp mode and found that NO activates the cyclic nucleotide-gated conductance, independent from cyclic GMP. As NO may also open calcium-dependent potassium channels and raise cyclic GMP levels, it appears to act as a complex modulator of olfactory receptor neuron physiology in vivo.
一氧化氮（NO）被认为是嗅觉上皮中的一种神经元信使。我们采用全细胞膜片钳模式分析了大鼠嗅觉受体神经元对NO刺激的电反应，发现NO可激活环核苷酸门控电导，且不依赖于环鸟苷酸（cGMP）。由于NO也可能开放钙依赖性钾通道并提高cGMP水平，因此它似乎在体内作为嗅觉受体神经元生理学的一种复杂调节剂发挥作用。
