术前血红蛋白水平在接受根治性放疗的不可手术非小细胞肺癌治疗中的重要性。
The importance of pre-treatment haemoglobin level in inoperable non-small cell lung carcinoma treated with radical radiotherapy.
作者信息
Langendijk Hans, de Jong Jos, Wanders Rinus, Lambin Philippe, Slotman Ben
机构信息
Department of Radiation Oncology, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands.
出版信息
Radiother Oncol. 2003 Jun;67(3):321-5. doi: 10.1016/s0167-8140(03)00057-4.
BACKGROUND AND PURPOSE
The purpose of this study was to evaluate the prognostic significance of the pre-treatment haemoglobin level among patients with inoperable non-small cell lung carcinoma (NSCLC) treated with definitive radiotherapy with regard to loco-regional tumour control (LC) and overall survival (OS).
MATERIAL AND METHODS
Patients (n=526) with previously untreated NSCLC, stages I-IIIb, WHO-performance status of 0-2 were eligible. All patients were treated with definitive external irradiation (60 Gy in 6 weeks).
RESULTS
In the multivariate analysis, the pre-treatment haemoglobin level was an independent prognostic factor for both loco-regional control and the overall survival.
CONCLUSIONS
pre-treatment haemoglobin levels are strongly associated with loco-regional tumour control and the overall survival.
背景与目的
本研究旨在评估接受根治性放疗的不可手术非小细胞肺癌（NSCLC）患者治疗前血红蛋白水平对局部区域肿瘤控制（LC）和总生存（OS）的预后意义。
材料与方法
纳入526例既往未接受治疗、分期为I - IIIb期、世界卫生组织体能状态为0 - 2级的NSCLC患者。所有患者均接受根治性外照射（6周内60 Gy）。
结果
多因素分析显示，治疗前血红蛋白水平是局部区域控制和总生存的独立预后因素。
结论
治疗前血红蛋白水平与局部区域肿瘤控制和总生存密切相关。
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