Wu De-hua, Liu Li, Chen Long-hua, Ding Yan-qing
Department of Radiation Oncology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Di Yi Jun Yi Da Xue Xue Bao. 2003 Jul;23(7):714-5, 719.
To study the expression of KAI1/CD82 in human colorectal tumor and its significance.
Immunohistochemistry was used to detect the expression of CD82 in 40 colorectal carcinoma, 20 lymphatic metastasis, 18 adenoma and 20 normal colorectal epithelium specimens, respectively.
The expression of CD82 was rather low in adenoma and normal colorectal epithelium, with the positivity rates of 25% and 10% respectively; 28 of the 40 colorectal carcinoma specimens were positive for CD82, resulting in a positivity rate of 70%. The rate for lymphatic metastasis was only 5%. The differences between the 4 groups were significant (P <0.05), and the expression of CD82 in the carcinoma was not related to the histological grades (P >0.05), but was associated with the presence of metastasis (P <0.05).
CD82 is related to the progression of colorectal carcinoma.
研究KAI1/CD82在人大肠肿瘤中的表达及其意义。
采用免疫组织化学法分别检测40例大肠癌、20例伴有淋巴结转移的大肠癌、18例腺瘤及20例正常大肠黏膜上皮组织中CD82的表达。
CD82在腺瘤及正常大肠黏膜上皮组织中表达较低，阳性率分别为25%和10%；40例大肠癌组织中28例CD82阳性，阳性率为70%。伴有淋巴结转移的大肠癌组织中CD82阳性率仅为5%。四组间差异有统计学意义（P<0.05），CD82在癌组织中的表达与组织学分级无关（P>0.05），但与有无转移有关（P<0.05）。
CD82与大肠癌的进展有关。
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