Yao Guo-jie, Ma Lian-ting, Wu Zuo-quan, Qin Shang-zhen
Department of Neurosurgery, Wuhan General Hospital of Guangzhou Command, Wuhan 430070, China.
Di Yi Jun Yi Da Xue Xue Bao. 2003 Jul;23(7):734-6.
To monitor the changes in the blood flow and blood-oxygen content in rat cerebral tissue with focal cerebral infarction using near-infrared spectroscopy (NIRS), so as to verify the value of NIRS in early diagnosis of cerebral infarction.
Focal cerebral infarction models were established in 16 rats by injecting silk threads into the internal carotid artery. The bilateral blood flow and blood-oxygen content were monitored with NIRS in the models and also in 16 normal rats receiving saline injection to serve as blank control group.
Focal cerebral infarction in rats caused the decrement in blood-oxygen content and the increase in blood flow. No changes were observed in the control group after saline injection (P >0.05).
In the earlier stages of focal cerebral infarction, blood-oxygen decreases while blood flow increases in the infarcted area. NIRS provides real-time, non-invasive monitoring of blood volume and blood-oxygen content in the cerebral tissue.
采用近红外光谱技术（NIRS）监测局灶性脑梗死大鼠脑组织血流及血氧含量变化，以验证NIRS在脑梗死早期诊断中的价值。
将丝线注入16只大鼠颈内动脉建立局灶性脑梗死模型。用NIRS监测模型组及16只注射生理盐水的正常大鼠（作为空白对照组）双侧血流及血氧含量。
大鼠局灶性脑梗死导致血氧含量降低、血流增加。注射生理盐水后对照组无变化（P>0.05）。
在局灶性脑梗死早期，梗死区域血氧降低而血流增加。NIRS可实时、无创地监测脑组织血容量及血氧含量。
