血清性激素、胰岛素样生长因子-1（IGF-1）和胰岛素样生长因子结合蛋白3（IGFBP3）对衰老过程中的瘦体重产生性别差异效应。

Serum Sex Hormones, IGF-1, and IGFBP3 Exert a Sexually Dimorphic Effect on Lean Body Mass in Aging.

作者信息

Waters Debra L, Yau C Lillian, Montoya George D, Baumgartner Richard N

机构信息

University of New Mexico-Health Sciences Center, Aging and Genetic Epidemiology Program, Albuquerque, 87131, USA.

出版信息

J Gerontol A Biol Sci Med Sci. 2003 Jul;58(7):648-52. doi: 10.1093/gerona/58.7.m648.

DOI:10.1093/gerona/58.7.m648

PMID:12865482

Abstract

BACKGROUND

Endogenous and exogenous sex hormones affect changes in body composition during aging via independent and dependent effects on the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and associated binding proteins (BP).

METHODS

Fasting serum IGF-1, IGFBP3, testosterone, estrone, and sex hormone binding globulin were analyzed in 48 women on hormone replacement (HRT) (unopposed oral estrogen, HRT+, 74.0 +/- 6 years), 135 women not on HRT (HRT-, 77.3 +/- 7 years), and 128 healthy men (men, ). Total lean body mass (LBM) and total fat were measured by dual energy X-ray absorptiometry.

RESULTS

Total LBM decreased with age in all groups (p = .05). LBM was greater, and IGF-1, IGFBP3, and testosterone were lower in HRT+ versus HRT- women (p = .02, p = .01, p = .04, and, respectively). LBM in men was positively related to IGF-1 (p = .02) and testosterone (p < .01), whereas LBM was associated with IGFBP3 (p = .04) and total fat (p < .001) in female HRT+ and total fat (p < .01) in HRT- women. IGF-1 decreased with age in men and HRT- women (p < .01) but did not decrease in HRT+ women. Total fat significantly decreased across age (p < .05). Controlling for age and HRT, the rate of decrease in fat was slower in men versus women (p = .02). IGFBP3 decreased in all groups across age (p < .01), and the ratio of IGF-1 to IGFBP3 decreased faster in men compared to HRT+ and HRT- women (p = .02).

CONCLUSIONS

Our data indicate divergent influences of sex steroids, IGF-1, and IGFBP3 on age-related changes in LBM in healthy elderly men and women.

摘要

背景

内源性和外源性性激素通过对生长激素/胰岛素样生长因子-1（GH/IGF-1）轴及相关结合蛋白（BP）的独立和依赖作用，影响衰老过程中身体成分的变化。

方法

对48名接受激素替代治疗（HRT）的女性（单纯口服雌激素，HRT+，74.0±6岁）、135名未接受HRT的女性（HRT-，77.3±7岁）和128名健康男性（男性，），分析空腹血清IGF-1、IGFBP3、睾酮、雌酮和性激素结合球蛋白。采用双能X线吸收法测量总体瘦体重（LBM）和总脂肪量。

结果

所有组的总体LBM均随年龄增长而下降（p = 0.05）。与HRT-女性相比，HRT+女性的LBM更高，而IGF-1、IGFBP3和睾酮更低（分别为p = 0.02、p = 0.01、p = 0.04）。男性的LBM与IGF-1（p = 0.02）和睾酮（p < 0.01）呈正相关，而在HRT+女性中LBM与IGFBP3（p = 0.04）和总脂肪量（p < 0.001）相关，在HRT-女性中LBM与总脂肪量（p < 0.01）相关。男性和HRT-女性的IGF-1随年龄增长而下降（p < 0.01），但HRT+女性中未下降。总脂肪量随年龄增长显著下降（p < 0.05）。在控制年龄和HRT因素后，男性脂肪量下降速度比女性慢（p = 0.02）。所有组的IGFBP3均随年龄增长而下降（p < 0.01），与HRT+和HRT-女性相比，男性中IGF-1与IGFBP3的比值下降更快（p = 0.02）。