Wade W G, Bishop P
Department of Oral Surgery, Dental School, Cardiff, UK.
Chemotherapy. 1992;38(5):330-4. doi: 10.1159/000239022.
The susceptibility of 106 oral bacteria to meropenem, a new carbapenem antimicrobial, penicillin V, tetracycline and metronidazole was assessed by an agar dilution method. Meropenem was the most effective of the antimicrobials, with all strains tested being inhibited at < or = 1 mg/l. A number of strains were resistant to penicillin V, particularly Bacteroides gracilis, and tetracycline resistance was widespread amongst the streptococci tested. Metronidazole was extremely effective against obligate anaerobes. The results of this study suggest that meropenem has potential for use in the treatment of serious head and neck infections.
采用琼脂稀释法评估了106种口腔细菌对新型碳青霉烯类抗菌药物美罗培南、青霉素V、四环素和甲硝唑的敏感性。美罗培南是最有效的抗菌药物，所有测试菌株在浓度≤1mg/l时均受到抑制。许多菌株对青霉素V耐药，尤其是纤细拟杆菌，并且在所测试的链球菌中四环素耐药很普遍。甲硝唑对专性厌氧菌极为有效。本研究结果表明美罗培南在治疗严重头颈部感染方面具有应用潜力。
