T细胞水平上与药物的交叉反应性。
Cross-reactivity with drugs at the T cell level.
作者信息
Depta Jan P H, Pichler Werner J
机构信息
Division of Allergology, Clinic of Rheumatology and Clinical Immunology / Allergology, Inselspital, University of Bern, Bern, Switzerland.
出版信息
Curr Opin Allergy Clin Immunol. 2003 Aug;3(4):261-7. doi: 10.1097/00130832-200308000-00005.
PURPOSE OF REVIEW
Cross-reactivity with drugs is an important clinical problem in drug hypersensitivity. Once a patient is labeled 'drug-allergic' all drugs of the same class are withheld and future therapeutic interventions are limited. Here we review cross-reactivity with drugs at the T cell level.
RECENT FINDINGS
Analysis of T cell recognition of various classes of drugs (beta-lactam antibiotics, sulfonamides, local anesthetics) using T cell clones suggests that at the T cell level the whole structure, in particular the core and to a lesser degree side chains, are recognized.
SUMMARY
It is necessary to differentiate cross-reactivity mediated by T cells and antibodies as only the latter seem to recognize side chains exclusively.
综述目的
药物交叉反应是药物超敏反应中的一个重要临床问题。一旦患者被标记为“药物过敏”，同一类别的所有药物都将停用，未来的治疗干预也会受到限制。在此，我们综述T细胞水平上的药物交叉反应。
最新发现
使用T细胞克隆分析T细胞对各类药物（β-内酰胺类抗生素、磺胺类药物、局部麻醉药）的识别表明，在T细胞水平上，整个结构，特别是核心结构，在较小程度上还有侧链，都会被识别。
总结
区分由T细胞和抗体介导的交叉反应很有必要，因为似乎只有后者能专门识别侧链。
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