Hervás I, Segura A, López-Tendero P, Bello P, González-Cabezas P, Flores D, Yuste A, Pérez-Velasco R, Girones R, Mateo A
Department of Nuclear Medicine, La Fe University Hospital, Valencia, Spain.
Q J Nucl Med. 2003 Jun;47(2):101-8.
The aim of this study is to assess the clinical impact of gallium-67 scintigraphy, before and after treatment, in patients with Hodgkin's disease, and to compare the overall survival between the patients whose gallium studies after treatment were negative and those whose studies remained positive.
We have studied 75 patients (40 women, 35 men) with Hodgkin's disease. All the patients underwent (67)Ga scintigraphy at the moment of the diagnosis (basal study) and in the case that basal study was positive (abnormal hyper-uptake focus) we performed follow-up studies after the treatment. We have calculated the overall survival among patients whose studies after treatment were negative (1(st) group) and those whose studies remained positive (2(nd) group) and between patients whose studies were negative at diagnosis (3(rd) group).
Gallium scintigraphy was positive at diagnosis in 47 patients (62.6%). In 39 of them we were able to perform the follow-up study after treatment. The follow-up study was negative in 31 patients while in 8 patients the gallium scintigraphy remained positive. The overall survival was significantly higher (p<0.001) in the 1(st) group compared with the 2(nd) group. The overall survival was higher in the 1(st) group compared with the 3(rd) but statistic significance level was not reached.
Our data suggest that: 1) in Hodgkin's disease (67)Ga scintigraphy is useful to establish the diagnosis of complete remission; 2) if the gallium scan remains positive after treatment, the prognosis of patients is worse than the prognosis of patients with a negative scan.
本研究旨在评估镓-67闪烁扫描术在霍奇金病患者治疗前后的临床影响，并比较治疗后镓扫描结果为阴性的患者与仍为阳性的患者的总生存率。
我们研究了75例霍奇金病患者（40例女性，35例男性）。所有患者在诊断时（基础研究）均接受了镓-67闪烁扫描术，若基础研究结果为阳性（异常高摄取灶），则在治疗后进行随访研究。我们计算了治疗后扫描结果为阴性的患者（第一组）、扫描结果仍为阳性的患者（第二组）以及诊断时扫描结果为阴性的患者（第三组）的总生存率。
47例患者（62.6%）诊断时镓闪烁扫描术结果为阳性。其中39例患者在治疗后能够进行随访研究。随访研究中，31例患者结果为阴性，8例患者镓闪烁扫描术仍为阳性。第一组的总生存率显著高于第二组（p<0.001）。第一组的总生存率高于第三组，但未达到统计学显著性水平。
我们的数据表明：1）在霍奇金病中，镓-67闪烁扫描术有助于确立完全缓解的诊断；2）若治疗后镓扫描仍为阳性，患者的预后比扫描结果为阴性的患者更差。
