Skórski T, Nieborowska-Skórska M, Calabretta B
Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107.
Folia Histochem Cytobiol. 1992;30(3):91-6.
A human Philadelphia-chromosome positive chronic myeloid leukemia-blast crisis (CML-BC) cell line BV173 proliferated in the hematopoietic tissues, infiltrated various organs and caused the death of immunodeficient SCID mice. Leukemia spreading was assessed with diminished number of bone marrow cells and caused splenomegaly. The leukemic colonies grew from single cell suspension of bone marrow, spleen and peripheral blood. Bcr-abl m-RNA was detectable in bone marrow, spleen, peripheral blood, liver, lungs and brain. Dying mice demonstrated severely hypoplastic bone marrow, splenomegaly and massive metastases in the liver and kidneys. The survival time of animals was dependent on the number of inoculated leukemia cells.
一种人费城染色体阳性慢性髓性白血病急变期（CML-BC）细胞系BV173在造血组织中增殖，浸润各种器官，并导致免疫缺陷的SCID小鼠死亡。通过骨髓细胞数量减少评估白血病扩散情况，其还导致脾肿大。白血病集落从骨髓、脾脏和外周血的单细胞悬液中生长。在骨髓、脾脏、外周血、肝脏、肺和脑中可检测到Bcr-abl信使核糖核酸。濒死小鼠表现出严重发育不全的骨髓、脾肿大以及肝脏和肾脏中的大量转移。动物的存活时间取决于接种的白血病细胞数量。
